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Effect of difelikefalin, a selective kappa opioid receptor agonist, on  respiratory depression<b>:</b> A randomized,
Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression<b>:</b> A randomized,

Difelikefalin - Wikipedia
Difelikefalin - Wikipedia

Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun  Dang Pharmaceutical Corporation For South Korean Mark
Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Mark

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or  approach-avoidance behavior occur differentially across the nucleus  accumbens shell rostro-caudal axis,Neuropharmacology - X-MOL
Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis,Neuropharmacology - X-MOL

κ-opioid receptor - Wikipedia
κ-opioid receptor - Wikipedia

Cara Therapeutics: Scratching At Multiple Indications In 2020 (NASDAQ:CARA)  | Seeking Alpha
Cara Therapeutics: Scratching At Multiple Indications In 2020 (NASDAQ:CARA) | Seeking Alpha

Molecules | Free Full-Text | Design of &kappa;-Opioid Receptor Agonists for  the Development of Potential Treatments of Pain with Reduced Side Effects
Molecules | Free Full-Text | Design of &kappa;-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects

Molecules | Free Full-Text | Design of &kappa;-Opioid Receptor Agonists for  the Development of Potential Treatments of Pain with Reduced Side Effects
Molecules | Free Full-Text | Design of &kappa;-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects

Cara Therapeutics: Scratching An Itch Left Unscratched (NASDAQ:CARA) |  Seeking Alpha
Cara Therapeutics: Scratching An Itch Left Unscratched (NASDAQ:CARA) | Seeking Alpha

Cara Therapeutics: Scratching An Itch Left Unscratched (NASDAQ:CARA) |  Seeking Alpha
Cara Therapeutics: Scratching An Itch Left Unscratched (NASDAQ:CARA) | Seeking Alpha

New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects
New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects

PDF) Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on  Respiratory Depression: A Randomized, Double‐Blind, Placebo‐Controlled Trial
PDF) Effect of Difelikefalin, a Selective Kappa Opioid Receptor Agonist, on Respiratory Depression: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Modulation of the kappa and mu opioid axis for the treatment of chronic  pruritus: A review of basic science and clinical implications -  ScienceDirect
Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications - ScienceDirect

Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class  of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink
Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands | SpringerLink

Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug  Development | SpringerLink
Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development | SpringerLink

EX-99.2
EX-99.2

A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus |  NEJM
A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus | NEJM

Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug  Development | SpringerLink
Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development | SpringerLink

New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects
New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects

Nephrology Journal Club on Twitter: "Difelikefalin (CR845) (KORSUVA) is a  peripherally restricted, selective kappa opioid receptor agonist that  exerts antipruritic effects by means of activation of kappa opioid  receptors on peripheral neurons
Nephrology Journal Club on Twitter: "Difelikefalin (CR845) (KORSUVA) is a peripherally restricted, selective kappa opioid receptor agonist that exerts antipruritic effects by means of activation of kappa opioid receptors on peripheral neurons

Difelikefalin: First Approval
Difelikefalin: First Approval

Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid  Agonists
Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid Agonists