News
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PADCEV™ Plus Keytruda® Significantly Improves Survival for Patients with Muscle-Invasive Bladder Cancer Regardless of Cisplatin Eligibility
Moitreyee Chatterjee-Kishore, PhD, MBA, Head of Oncology Development, Astellas“Building on the recent U.S. approval for cisplatin-ineligible patients living with MIBC, these positive EV-304 findings reinforce the potential of PADCEV plus pembrolizumab to improve survival outcomes for a broad population of patients living with muscle-invasive bladder cancer. Together with the EV-303 data, these results strengthen the evidence supporting this combination regimen…
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The 25 Best TV Shows of 2025 | TV/Streaming
It’s that time of year when critics look back and try to capture the quality of an entire art form in one feature. Was it a good year for TV? Sure. Great? Maybe? It feels like the top of this list contains programs that will undeniably be remembered when we’re discussing the best of the decade or even of their…
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Five Essential Rob Reiner Movies
The tragedy surrounding the murder of Rob Reiner and his wife, Michele, has shaken the industry to its core, and it’s something that will continue to linger as more facts emerge. In times like this, sometimes the lone bright spot when someone so talented and prolific leaves us is that they leave behind a body of work that allows their…
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John Catsimatidis on Donald Trump, Immigration, and New York Republicans
John Catsimatidis — a businessman, Republican, political donor, radio host and station owner, 2013 candidate for New York City mayor, Donald Trump ally, and (former) Curtis Sliwa employer — spoke with The New York Editorial Board on the morning of December 11, 2025. (photo via Red Apple Group) Participating journalists: Nicole Gelinas, Josh Greenman, Alyssa Katz, Ben Smith, Liena Zagare. Catsimatidis…
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Secretary Bessent Orders Sanctions Against Violent Mexican Cartel
WASHINGTON — Today, the U.S. Department of the Treasury’s Office of Foreign Assets Control (OFAC) sanctioned the Cartel de Santa Rosa de Lima (CSRL), which derives the vast majority of its illicit revenue from fuel and oil theft in the Mexican state of Guanajuato. The violent conflict between CSRL and the notorious Mexican terrorist Cartel Jalisco Nuevo Generacion (CJNG) for…
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Kyrgyzstan’s USDKG Shows How Gold-Backed Stablecoins Are Evolving
Key takeaways Kyrgyzstan has launched USDKG, a USD-pegged stablecoin that the project says is backed by physical gold rather than cash and short-term US Treasurys. The token was first deployed on Tron with a reported initial issuance of 50 million units, with plans to expand to Ethereum. This article explains why gold-reserve narratives and state-linked structures can appeal in remittance-heavy…
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Efficacy of a digital health application for weight management in people with obesity: 6-months results from a randomized controlled trial
Study design This study was a prospective decentralized randomized controlled trial with technology-enabled, remote recruitment, care delivery, and data collection conducted in Germany. The study’s primary endpoint was defined as the change in body weight assessed at 6 months of intervention. The study had a crossover design with participants in the intervention group continuing to receive the intervention for an…
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Why the weirdest sea level changes on Earth are happening off the coast of Japan
Bathtubs and pools mislead us about the ocean: Its surface is anything but flat. Seas pile up in some spots, pushed by trade winds or pulled by gravity toward big things like ice sheets. Amid it all, at the western end of large ocean basins, the fastest surface currents — veins of warm water — race toward the poles, causing…
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10 Greatest Action Movie Moments of 2025, Ranked
You can pretty much always rely on something from the action genre to deliver in any given year, unless you’re talking about 2020, maybe, when lots of the bigger action movies got delayed (but hey, even then, Tenet did still come out… for better or worse). People like action scenes, and so people like action movies. Barring a global pandemic…
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Have complete faith in the law enforcement authorities: Shilpa Shetty
Shilpa Shetty and Raj Kundra (X) Mumbai: Actor Shilpa Shetty and husband Raj Kundra on Wednesday categorically denied allegations against them a day after Bengaluru police registered a case against their restaurant for operating beyond permitted hours. The celebrity couple is also fighting allegations of duping a businessman of Rs 60 crore in an investment deal. In a joint statement…
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