clumps
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Scientists melt early protein clumps and shut down Alzheimer’s damage
Researchers at Tokyo Metropolitan University have turned to concepts from polymer physics to better understand a central feature of Alzheimer’s disease: the formation of tau protein fibrils. Their work revealed that these fibrils do not appear suddenly. Instead, they emerge after large clusters of tau proteins begin to gather in solution, a process that resembles polymer crystallization. When the scientists…
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Tiny protein dismantles the toxic clumps behind Alzheimer’s
Scientists at St. Jude Children’s Research Hospital demonstrated for the first time that the protein midkine plays a preventative role against Alzheimer’s disease. Midkine is known to accumulate in Alzheimer’s disease patients. Now, researchers have connected it with amyloid beta, a protein that accumulates in the brain, causing assemblies that are a hallmark of Alzheimer’s. In work published on August…
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Scientists crack the mystery of brain cell clumps, and make them vanish
Look inside a brain cell with Huntington’s disease or ALS and you are likely to find RNA clumped together. These solid-like clusters, thought to be irreversible, can act as sponges that soak up surrounding proteins key for brain health, contributing to neurological disorders. How these harmful RNA clusters form in the first place has remained an open question. Now, University…
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