Once you have all that stuff stored safely in such a remote location, there’s a reasonable argument that you no longer need it also taking up space on your own local PC (unless you simply want the redundancy as an extra fail-safe and backup, of course).
You can address this in several ways: First, you can hide certain folders so they don’t sync to your PC. For example, in OneDrive, right-click the OneDrive cloud icon in your system tray, select “Settings,” click the “Account” option, and then click “Choose folders.” You can then uncheck certain folders, and they will never sync to your PC.
OneDrive also downloads files “on demand” as you use them. You can right-click big files in File Explorer and select “Free up space” to save space on your computer. The next time you open that file, OneDrive will automatically redownload it — but it won’t exist in both places and take up room in the meantime.
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