The NHS trust that runs 999 and 111 services across Berkshire, Buckinghamshire, Oxfordshire and Hampshire has urged patients who take regular medication to plan ahead to avoid running out.
South Central Ambulance Service (SCAS) said urgent calls for repeat prescriptions had risen sharply over the past year and asked people to be aware of what they needed, especially before bank holidays.
New figures show calls to 111 for urgent repeat prescriptions rose by 61%, with demand highest on bank holidays when the service is already busy.
It said other alternatives rather than calling 111 included using the NHS app and 111 online, with both free to use and usually quicker than phoning.
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