World Health Organisation. Cardiovascular diseases (CVDs) [Internet]. 2025 [cited 2025 Aug 6]; Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
World Health Organisation. Obesity and overweight [Internet]. 2025 [cited 2025 Aug 6]; Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
World Health Organisation. Diabetes [Internet]. 2025 [cited 2025 Aug 6]; Available from: https://www.who.int/news-room/fact-sheets/detail/diabetes.
Zhang, D. et al. Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study. BMJ Open 9, e024476 (2019).
Google Scholar
Cheng, X. et al. Trends in the prevalence of cardiometabolic multimorbidity in the United States, 1999–2018. Int J. Environ. Res. Public Health 19, 4726 (2022).
Google Scholar
Lavie, C. J. et al. Management of cardiovascular diseases in patients with obesity. Nat. Rev. Cardiol. 15, 45–56 (2018).
Google Scholar
Roeters van Lennep, J. E. et al. Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society. Eur. Heart J. 44, 4157–4173 (2023).
Google Scholar
Barker, D. J. P. & Bagby, S. P. Developmental antecedents of cardiovascular disease: a historical perspective. J. Am. Soc. Nephrol. 16, 2537–2544 (2005).
Google Scholar
Cochrane, A. L. K., Murphy, M. P., Ozanne, S. E. & Giussani, D. A. Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring. Eur. Heart J. 45, 5127–5145 (2024).
Google Scholar
Guenard, F. et al. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. PNAS 110, 11439–11444 (2013).
Google Scholar
Van De Maele, K., Devlieger, R. & Gies, I. In utero programming and early detection of cardiovascular disease in the offspring of mothers with obesity. Atherosclerosis 275, 182–195 (2018).
Google Scholar
Smith, J. et al. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J. Clin. Endocrinol. Metab. 94, 4275–4283 (2009).
Google Scholar
Schoonejans, J. M. & Ozanne, S. E. Developmental programming by maternal obesity: lessons from animal models. Diabet. Med. 38, e14694 (2021).
Google Scholar
Reynolds, C. M., Vickers, M. H. Utility of Small Animal Models of Developmental Programming [Internet]. In: Guest P. C., editor. Investigations of Early Nutrition Effects on Long-Term Health: Methods and Applications. New York, NY: Springer; 2018 [cited 2023 Jan 23]. 145–163. Available from: https://doi.org/10.1007/978-1-4939-7614-0_8.
Itani, N. et al. The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo. J. Physiol. 596, 2991–3006 (2018).
Google Scholar
Lombardo, S. D., Wangsaputra, I. F., Menche, J. & Stevens, A. Network approaches for charting the transcriptomic and epigenetic landscape of the developmental origins of health and disease. Genes 13, 764 (2022).
Google Scholar
Shashikadze, B. et al. Developmental effects of (Pre-)gestational diabetes on offspring: systematic screening using omics approaches. Genes 12, 1991 (2021).
Google Scholar
Ozen, M. et al. Omics approaches: interactions at the maternal-fetal interface and origins of child health and disease. Pediatr. Res. 93, 366–375 (2023).
Google Scholar
Fleury, E. S. et al. Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors. Pediatr. Res. https://doi.org/10.1038/s41390-025-04322-4 (2025).
Google Scholar
Fernandez-Twinn, D. S. et al. Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and male offspring insulin sensitivity. Sci. Rep. 7, 44650 (2017).
Google Scholar
Beeson, J. H. et al. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol. Metab. 16, 35–44 (2018).
Google Scholar
Burden, S. J. et al. Maternal obesity and offspring cardiovascular remodelling – the effect of preconception and antenatal lifestyle interventions: a systematic review. Int J. Obes. 48, 1045–1064 (2024).
Google Scholar
Rice, M. M. et al. Pregnancy-associated hypertension and offspring cardiometabolic health. Obstet. Gynecol. 131, 313–321 (2018).
Google Scholar
Yuan, W. L. et al. The adverse influence of maternal glycaemia during pregnancy on offspring’s cardiometabolic health profiles. Acta Paediatr. 114, 2287–2297 (2025).
Google Scholar
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